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Your Position: 홈 > IL-31 RA

IL-31 RA

요약

Name:Interleukin-31 receptor subunit alpha
Target Synonym:GLM-R,CRL,IL-31R subunit alpha,IL-31 receptor subunit alpha,Cytokine receptor-like 3,Gp130-like monocyte receptor,IL-31RA,ZcytoR17,IL-31R-alpha,PRO21384,GPL,CRL3,GLMR,Interleukin 31 Receptor A,Soluble Type I Cytokine Receptor CRL3,PLCA2,Class I Cytokine Receptor,hGLM-R,Gp130-like receptor
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

제품 리스트 구매

제품> 결과 필터링
제품 상태별:
제품 유형별 :
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결합물별:
제품번호 종 제품 설명 구조 순도 특징
ILA-H82F6 Human Biotinylated Human IL-31 RA Protein, Fc,Avitag™
ILA-H82F6-sds
ILA-M5254 Mouse Mouse IL-31 RA Protein, Fc Tag
ILA-M5254-structure
ILA-M5254-sds
ILA-H525b Cynomolgus / Rhesus macaque Cynomolgus/Rhesus macaque IL-31 RA Protein, Fc Tag
ILA-H525b-structure
ILA-H525b-sds
ILA-H82E9 Human Biotinylated Human IL-31 RA Protein, His,Avitag™
ILA-H82E9-structure
ILA-H82E9-sds
ILA-H52H7 Human Human IL-31 RA Protein, His Tag (MALS & SPR verified)
ILA-H52H7-structure
ILA-H52H7-sds
ILA-H5256 Human Human IL-31 RA Protein, Fc Tag
ILA-H5256-structure
ILA-H5256-sds

일부의 생물활성 데이터

ILA-H52H7-SPR
IL-31 RA SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) immobilized on CM5 Chip can bind Human IL-31 RA, His Tag (Cat. No. ILA-H52H7) with an affinity constant of 52.1 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
ILA-H5256-SPR
IL-31 RA SPR

Human IL-31, His Tag (Cat. No. IL1-H5247) capture on NTA-Series S sensor chip can bind Human IL-31 RA, Fc Tag (Cat. No. ILA-H5256) with an affinity constant of 37.1 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Synonym Name

IL-31 RA,IL-31RA,hGLM-R,CRL3,GPL,ZcytoR17,GLM-R,IL-31R-alpha,Gp130-like receptor

Background

Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.

Clinical and Translational Updates

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